Pacing to prevent vasovagal syncope

Patients with frequent vasovagal syncope have markedly poor quality of life and are often resistant to treatment with standard pharmacologic approaches. Vasovagal syncope is due to combinations of bradycardia and hypotension. There is accumulating evidence that many of these patients may respond to permanent cardiac pacing. Several controlled open-label studies suggest that about half of paced patients no longer faint, and most of the rest are improved. At this point, we do not know the role of placebo, and specific pacing modes in this improvement are not known. Ongoing trials will clarify how to select patients and how best to pace them.