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Warning! Nearby construction can profoundly affect your experiments.

M F Dallman1, S F Akana, M E Bell

  • 1Department of Physiology, University of California San Francisco, 94143-0444, USA. dallman@itsa.ucsf.edu

Endocrine
|March 10, 2000
PubMed
Summary
This summary is machine-generated.

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Construction projects can disrupt animal research by altering stress hormones and energy balance. Our study highlights the need to monitor these factors to ensure reliable scientific results.

Area of Science:

  • Environmental Science
  • Animal Behavior
  • Physiology

Background:

  • Construction projects can cause environmental disruptions.
  • Previous research has shown construction impacts stress hormones in animals.
  • The effects on energy balance were not previously anticipated.

Purpose of the Study:

  • To alert researchers to the potential impacts of construction on research outcomes.
  • To investigate the disruption of energy balance due to environmental perturbations.
  • To highlight the need for monitoring animal well-being during construction.

Main Methods:

  • Monitoring daily weights and food intake in rats and mice.
  • Measuring stress hormone levels (ACTH and corticosterone).
  • Observing physiological responses to environmental changes.

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Main Results:

  • Construction significantly affects animal stress hormone levels.
  • Environmental disruptions caused unexpected changes in energy balance.
  • Two examples of energy balance disruption are provided.

Conclusions:

  • Environmental perturbations from construction can significantly impact animal research.
  • Researchers must consider and monitor energy balance in addition to stress hormones.
  • Awareness and monitoring are crucial for maintaining research integrity during construction.