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Evidence that mouse thyroid stimulator does not stimulate the human thyroid gland.
Australian and New Zealand Journal of Medicine
|August 1, 1976
Summary
Mouse thyroid stimulator (MTS) does not affect human thyroid function. Human thyroid stimulator (HTS) levels strongly correlate with thyroid 131I uptake in thyrotoxic patients, even with MTS presence.
Area of Science:
- Endocrinology
- Thyroidology
Background:
- Thyrotoxicosis is often associated with thyroid stimulators.
- Mouse thyroid stimulator (MTS) is a known thyroid stimulator in animal models.
- The role of MTS in human thyroid function is not well understood.
Purpose of the Study:
- To investigate the correlation between human thyroid stimulator (HTS) levels, mouse thyroid stimulator (MTS) activity, and thyroid 131I uptake in untreated thyrotoxic patients.
- To determine if MTS influences the relationship between HTS and thyroid uptake in humans.
Main Methods:
- Measured thyroid 131I uptake and HTS levels in 20 untreated thyrotoxic patients.
- Assessed for the presence of MTS activity in the same patient cohort.
- Analyzed correlations between HTS, MTS, and thyroid uptake using statistical methods.
Main Results:
- A highly significant positive correlation was found between HTS levels and thyroid 131I uptake (r=0.66, P<0.005).
- This correlation remained significant despite varying levels of MTS activity.
- No significant correlation was observed between MTS levels and thyroid 131I uptake (r=0.11, n.s.).
Conclusions:
- Human thyroid stimulator (HTS) levels are a reliable indicator of thyroid 131I uptake in thyrotoxic patients.
- Mouse thyroid stimulator (MTS) does not stimulate the human thyroid gland.
- The presence of MTS does not interfere with the established relationship between HTS and thyroid uptake in humans.