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Related Experiment Videos

Just a little heartburn?

J A Green1, R Amaro, J S Barkin

  • 1University of Miami, School of Medicine/Mt. Sinai Medical Center, Division of Gastroenterology, Florida, USA.

The American Journal of Gastroenterology
|March 10, 2000
PubMed
Summary

Gastroesophageal reflux (GER) significantly increases the risk of esophageal adenocarcinoma. The likelihood of developing this cancer rises with the frequency, severity, and duration of GER symptoms.

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Area of Science:

  • Gastroenterology
  • Oncology
  • Epidemiology

Background:

  • Gastroesophageal reflux (GER) is a common condition.
  • The link between GER and esophageal adenocarcinoma requires further investigation.

Purpose of the Study:

  • To examine the association between GER and esophageal and gastric cardia adenocarcinoma.
  • To determine if GER symptom characteristics influence cancer risk.

Main Methods:

  • Population-based, case-control study design.
  • Analysis of GER symptoms in relation to esophageal and gastric cardia cancers.

Main Results:

  • An odds ratio of 7.7 was found for esophageal adenocarcinoma in patients with GER symptoms.
  • Increased frequency, severity, and duration of GER symptoms correlated with higher esophageal adenocarcinoma risk.
  • A weaker association was observed for GER and gastric cardia adenocarcinoma.
  • No association was found between GER and esophageal squamous cell carcinoma.

Conclusions:

  • GER is a significant risk factor for esophageal adenocarcinoma.
  • GER symptom characteristics are important determinants of cancer risk.
  • GER does not appear to be associated with squamous cell carcinoma of the esophagus.

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