Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Exploring structure space. A protein structure initiative.

T C Terwilliger1, J Berendzen

  • 1Los Alamos National Laboratory, NM 87545, USA.

Genetica
|March 11, 2000
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Recurrent perineal hernia repair: a novel approach.

Hernia : the journal of hernias and abdominal wall surgery·2011
Same author

Structural studies of bee melittin.

Biophysical journal·2009
Same author

High throughput crystallography of TB drug targets.

Infectious disorders drug targets·2007
Same author

Bayesian correlated MAD phasing.

Acta crystallographica. Section D, Biological crystallography·2004
Same author

SAD phasing by combination of direct methods with the SOLVE/RESOLVE procedure.

Acta crystallographica. Section D, Biological crystallography·2004
Same author

The TB structural genomics consortium: a resource for Mycobacterium tuberculosis biology.

Tuberculosis (Edinburgh, Scotland)·2003
Same journal

Morphological and COI-based identification of species of the Hawkmoth genus Theretra Hübner, 1819 (Lepidoptera: Sphingidae) from Himachal Pradesh, India.

Genetica·2026
Same journal

Advancing genetics and evolution: new Editors-in-Chief in Genetica.

Genetica·2026
Same journal

Origin and diversification of Altai osmans (Oreoleuciscus), Far Eastern phoxinin minnows (Rhynchocypris) and Far Eastern redfins (Tribolodon) of the Leuciscidae family (Actinopterygii): an example of evolutionary tempo variation?

Genetica·2026
Same journal

Chloroplast genome comparison, phylogeny, and molecular evolution of five endemic Potentilla (Rosaceae) species in Mongolia.

Genetica·2026
Same journal

Severe trauma and chronic stress: seeds and fruits of epigenetic sensitivity.

Genetica·2026
Same journal

Molecular evolution and antigenic mapping of classical swine fever virus: a comprehensive analysis of E2 genomic variability and selection dynamics.

Genetica·2026
See all related articles

Genome projects provide genetic blueprints, but protein structure and function remain elusive. This paper proposes a large-scale initiative to determine protein structures, integrating this data for a comprehensive understanding of life.

Area of Science:

  • Genomics
  • Structural Biology
  • Proteomics

Background:

  • Genome projects offer genetic blueprints but lack detailed protein structure and function information.
  • Understanding protein structures is crucial for deciphering biological processes.
  • Current knowledge gaps hinder a complete understanding of life at the molecular level.

Purpose of the Study:

  • To present an approach for obtaining protein structural information on a genomic scale.
  • To outline how structural and functional data can be integrated for a comprehensive biological understanding.
  • To propose a large-scale initiative for determining protein structures.

Main Methods:

  • Describing a novel approach for large-scale protein structure determination.
  • Integrating structural information with functional data.

Related Experiment Videos

  • Identifying protein classes benefiting from genomic structural analysis.

    • Main Results:

    • The proposed approach enables structural information acquisition on a genomic scale.
    • Structural data integration provides a foundation for describing life at multiple levels.
    • Specific protein classes are identified as high-priority targets for structural studies.

    Conclusions:

    • A genomic-scale approach to protein structure determination is feasible and necessary.
    • Integrating structural and functional data is key to a holistic understanding of biological systems.
    • A large-scale initiative is proposed to advance structural biology and genomics.