Related Experiment Video
Updated: Aug 11, 2026

Single Cell Collection of Trophoblast Cells in Peri-implantation Stage Human Embryos
Published on: June 12, 2020
The role of HOX genes in human implantation
1Department of Obstetrics and Gynecology, Yale University School of Medicine, New Haven, Connecticut, USA. hugh.taylor@yale.edu
Abstract:
HOX genes are transcriptional regulators that play an essential role in determining tissue identity during embryonic development. HOX genes are involved in the development of the Müllerian system and then continue to be expressed in the adult uterus. Two HOX genes have been demonstrated necessary for uterine receptivity in knock-out mice. We have recently elucidated the expression patterns and regulation of HOX genes in the development of the human endometrium during the menstrual cycle. HOX genes are likely key regulators of human implantation. This paper will review the role of HOX genes in the reproductive tract, specifically the evidence that HOX genes are important for human endometrial development and receptivity.
Related Concept Videos
Cleavage and Blastulation
Gastrulation
Genomic Imprinting and Inheritance
The expression of some genes depends on which parent passed the gene to the offspring, through a phenomenon known as...
Hedgehog Signaling Pathway
Zygotic Development And Stem Cell Formation
Development of the Sexual Organs in the Embryo and Fetus
Near the gonadal ridges, two duct systems are present: the mesonephric ducts (Wolffian ducts) and paramesonephric ducts (Müllerian ducts). These ducts form the basis for the male...

