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Malignant granular cell tumor metastatic to the orbit
S A Callejo1, J W Kronish, S J Decker
1Bascom Palmer Eye Institute, University of Miami School of Medicine, Florida 33101, USA.
Ophthalmology
|March 11, 2000
Summary
Malignant granular cell tumor, a rare soft tissue sarcoma, can metastasize to the orbit. This case report details the first instance of orbital metastasis from this rare cancer.
Area of Science:
- Oncology
- Ophthalmology
- Pathology
Background:
- Malignant granular cell tumor (MGCT) is a rare soft tissue sarcoma.
- Ocular involvement by MGCT is exceptionally rare, with only two prior cases reported.
Observation:
- A 72-year-old male presented with proptosis and motility disturbance.
- Imaging revealed a large intraconal orbital mass, confirmed as MGCT via biopsy.
- Histopathology showed increasing atypia in consecutive lesions, supported by S-100 protein expression.
Findings:
- This case represents the first documented instance of MGCT metastasizing to the orbit.
- The primary tumor was in the cervical region, with subsequent orbital and distant metastases (bone, lung).
Implications:
- Orbital metastasis should be considered in the differential diagnosis of orbital masses.
- This finding expands the known metastatic potential of malignant granular cell tumors.