Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Immunomodulation by 8-week voluntary exercise in mice.

H Sugiura1, H Nishida, R Inaba

  • 1Department of Health and Physical Education, Gifu Pharmaceutical University, 5-6-1 Mitahora higashi, Gifu, Japan.

Acta Physiologica Scandinavica
|March 11, 2000
PubMed
Summary

Voluntary exercise significantly boosts macrophage and lymphocyte immune functions in mice. This study recommends measuring nitric oxide (NO2-) production to assess macrophage activity in exercise research.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Evidence for the covalent binding of SHAP, heavy chains of inter-alpha-trypsin inhibitor, to hyaluronan.

The Journal of biological chemistry·1995
Same author

[Clean intermittent catheterization in neurogenic bladder patients with vesicoureteral reflux].

Nihon Hinyokika Gakkai zasshi. The japanese journal of urology·1995
Same author

[A trial of antegrade perfusion to the lower half of the body with selective cerebral perfusion for repair of aortic arch aneurysm combined with atherosclerosis obliterance].

Kyobu geka. The Japanese journal of thoracic surgery·1995
Same author

Inhibition of intestinal tumor development in rat multi-organ carcinogenesis and aberrant crypt foci in rat colon carcinogenesis by 22-oxa-calcitriol, a synthetic analogue of 1 alpha, 25-dihydroxyvitamin D3.

Carcinogenesis·1995
Same author

Varus derotation osteotomy for persistent dysplasia in congenital dislocation of the hip. Proximal femoral growth and alignment changes in the leg.

The Journal of bone and joint surgery. British volume·1995
Same author

Effects of chondroitinase ABC on degenerative intervertebral discs.

Clinical orthopaedics and related research·1995

Area of Science:

  • Immunology
  • Exercise Physiology
  • Cell Biology

Background:

  • Immune cell function is crucial for overall health.
  • The impact of voluntary exercise on immune cell activity requires further investigation.

Purpose of the Study:

  • To evaluate the effects of voluntary exercise on macrophage and lymphocyte functions in mice.
  • To determine if voluntary exercise enhances immune cell responsiveness.

Main Methods:

  • Male A/He inbred mice were divided into exercise and control groups.
  • Mice underwent voluntary wheel running for 8 weeks.
  • Macrophage and lymphocyte functions were assessed via glucose consumption, enzyme activities, nitric oxide production, and cytokine release.

Main Results:

Related Experiment Videos

  • Exercise group showed significantly higher macrophage glucose consumption and enzyme activities (acid phosphatase, beta-glucuronidase, lactate dehydrogenase).
  • Macrophage nitric oxide (NO2-) production stimulated by lipopolysaccharide (LPS) was approximately doubled in the exercise group.
  • Lymphocyte stimulation indices and interleukin-2 (IL-2) production were significantly elevated in mice that exercised voluntarily.

Conclusions:

  • Voluntary exercise enhances both macrophage function and lymphocyte responsiveness in mice.
  • Nitric oxide (NO2-) production is a recommended indicator for evaluating macrophage function in voluntary exercise studies.