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Synthesis of bioprocesses using physical properties data.
M A Steffens1, E S Fraga, I D Bogle
1Department of Chemical Engineering, University College London, Torrington Place, London, WC1E 7JE, United Kingdom.
Biotechnology and Bioengineering
|March 11, 2000
Summary
This study presents a novel synthesis procedure for bioprocesses, utilizing physical property information to efficiently screen and design process units. The method generates ranked, economically optimal flowsheets for complex bioprocesses.
Area of Science:
- Biochemical Engineering
- Process Systems Engineering
- Computational Chemistry
Background:
- Bioprocess development involves complex separation challenges due to numerous components.
- Existing synthesis methods require adaptation for the unique demands of bioprocesses.
- Efficient design of bioprocesses is crucial for economic viability.
Purpose of the Study:
- To evaluate an extended synthesis procedure for designing complex bioprocesses.
- To demonstrate the application of physical property-based screening for unit selection.
- To validate a computational methodology for generating optimal bioprocess flowsheets.
Main Methods:
- Incorporation of a screening technique based on physical property differences.
- Integration of bioprocess-unit-design methodologies into an implicit enumeration algorithm.
- Development of bioprocess synthesis software implemented in Java.
Main Results:
- The methodology successfully screens candidate units, reducing problem size for bioprocess synthesis.
- The software generates a ranked list of flowsheets, facilitating detailed analysis.
- Two case studies, including a challenging intracellular product system, were effectively addressed.
Conclusions:
- The synthesis methodology efficiently handles large and complex bioprocess design problems.
- The approach identifies economically optimal flowsheets within reasonable computational time.
- System-wide optimization of bioprocesses is achievable, moving beyond unit-by-unit design.