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INFLUENCE OF BASELINE VALUES ON LIPIDS, LIPOPROTEINS AND FIBRINOLYTIC PARAMETERS DURING TREATMENT OF HYPERTENSION

Ahaneku1, Sakata, Urano

  • 1Department of Physiology and Pathophysiology, Hamamatsu University School of Medicine, 3600 Handa-cho, Hamamatsu-shi, Shizuoka-ken, 431*b13192

Pharmacological Research
|March 14, 2000
PubMed

Insights

Cilnidipine treatment improved lipid profiles in hypertensive patients with high baseline lipid levels, showing beneficial changes in cholesterol and triglycerides. The drug

Area of Science:

  • Cardiology
  • Pharmacology
  • Biochemistry

Background:

  • Hypertension is a significant risk factor for cardiovascular disease.
  • Lipid profiles play a crucial role in cardiovascular health.
  • Understanding the impact of antihypertensive drugs on lipid metabolism is essential.

Purpose of the Study:

  • To investigate the effects of cilnidipine on serum lipids, lipoproteins, and fibrinolytic parameters in hypertensive patients.
  • To determine if baseline lipid profile influences cilnidipine's effects.
  • To explore the relationship between lipid changes, fibrinolysis, and blood pressure reduction.

Main Methods:

  • 16 adult hypertensive patients were enrolled.
  • Patients were categorized into 'medium' and 'high' baseline total lipid profile groups.
  • Evaluations included serum lipids, lipoproteins, and plasma fibrinolytic parameters after 3 months of cilnidipine treatment.

Main Results:

  • Patients with 'medium' baseline lipid values showed no significant changes.
  • Patients with 'high' baseline lipid values exhibited beneficial changes: decreased total cholesterol, triglycerides, VLDL-C; increased HDL-C and HDL-C/TC ratio.
  • Lipid changes were associated with fibrinolysis differently based on baseline levels; blood pressure reduction correlated with fibrinolysis and reduced coronary heart disease risk in the 'high' baseline group.

Conclusions:

  • Cilnidipine's lipid-altering effects are influenced by baseline lipid profile levels.
  • The interaction between lipids and fibrinolysis during cilnidipine treatment varies with baseline lipid status.
  • Cilnidipine may offer cardiovascular benefits beyond blood pressure reduction, particularly in patients with dyslipidemia.

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