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A-kinase anchoring proteins: protein kinase A and beyond
1Howard Hughes Medical Institute, Vollum Institute, Oregon Health Sciences University, Portland, OR 97201, USA.
Current Opinion in Cell Biology
|March 14, 2000
Abstract:
Compartmentalization of kinases and phosphatases is a key determinant in the specificity of second messenger mediated signaling events. Localization of the cAMP-dependent protein kinase (PKA) and other signaling enzymes is mediated by interaction with A-kinase anchoring proteins (AKAPs). In the past year there have been many advances in our understanding of AKAPs, particularly in the field of the functional consequences of PKA anchoring.