Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

DNA replication at high resolution.

J L Keck1, J M Berger

  • 1Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720, USA.

Chemistry & Biology
|March 14, 2000
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Trastuzumab in Addition to Chemotherapy in Patients With Metastatic Human Epidermal Growth Factor Receptor 2-Positive Gastroesophageal Cancer-A Real-World Experience.

Clinical oncology (Royal College of Radiologists (Great Britain))·2026
Same author

Peripheral blood DNA methylation profile and immune checkpoint inhibitor response in cancer patients.

ESMO open·2026
Same author

Predictive potential of patient-specific immunological characteristics in solid cancers: circulating monocytes, myeloid-derived suppressor cells, T cells, and the T-cell receptor repertoire.

ESMO open·2026
Same author

Prognosticators of survival in patients with metastatic pancreatic cancer and ascites.

ESMO open·2023
Same author

Clinical risk factors for ascites in metastatic pancreatic cancer.

ESMO open·2023
Same author

Precursor-product relationships of Poly(γ-glutamylcysteinyl)glycine biosynthesis in Datura innoxia.

Plant cell reports·2013
Same journal

The Hedgehog Pathway Effector Smoothened Exhibits Signaling Competency in the Absence of Ciliary Accumulation.

Chemistry & biology·2017
Same journal

DIVERSE System: De Novo Creation of Peptide Tags for Non-enzymatic Covalent Labeling by In Vitro Evolution for Protein Imaging Inside Living Cells.

Chemistry & biology·2015
Same journal

Differential Regulation of Specific Sphingolipids in Colon Cancer Cells during Staurosporine-Induced Apoptosis.

Chemistry & biology·2015
Same journal

Synthetic Peptides as cGMP-Independent Activators of cGMP-Dependent Protein Kinase Iα.

Chemistry & biology·2015
Same journal

Unraveling the B. pseudomallei Heptokinase WcbL: From Structure to Drug Discovery.

Chemistry & biology·2015
Same journal

Vitamin C as Cancer Destroyer, Investigating Sulfhydration, and the Variability in CFTR Interactome.

Chemistry & biology·2015
See all related articles

This review details protein functions in DNA replication, focusing on structural insights from the last 15 years and recent breakthroughs in replication machinery.

Area of Science:

  • Molecular Biology
  • Structural Biology
  • Biochemistry

Background:

  • DNA replication is a fundamental biological process essential for cell division and organismal development.
  • Decades of research have identified numerous proteins critical for accurate and efficient DNA replication.

Purpose of the Study:

  • To provide a structural perspective on DNA replication proteins.
  • To highlight recent advances in understanding DNA replication mechanisms over the past 15 years.

Main Methods:

  • Review of existing structural data and research findings.
  • Analysis of key protein structures involved in DNA replication.
  • Synthesis of recent experimental results and their structural implications.

Main Results:

Related Experiment Videos

  • Detailed structural insights into the dynamic nature of replication proteins.
  • Identification of key structural motifs enabling protein-protein interactions.
  • Elucidation of how structural changes facilitate replication initiation, elongation, and termination.

Conclusions:

  • Structural biology has significantly advanced our understanding of DNA replication.
  • Recent structural studies reveal novel mechanisms and regulatory pathways in DNA replication.
  • Continued structural investigation promises further insights into maintaining genome stability.