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Increased exhaled nitric oxide in chronic bronchitis: comparison with asthma and COPD
F M Delen1, J M Sippel, M L Osborne
1Portland Veterans Administration Medical Center, Portland, OR 97201, USA.
Chest
|March 14, 2000
Summary
Exhaled nitric oxide (NO) is elevated in chronic bronchitis and asthma patients, but not in COPD. Highest NO levels were observed in individuals with both chronic bronchitis and asthma, suggesting shared inflammatory pathways.
Area of Science:
- Respiratory Medicine
- Biomarkers
- Pulmonary Inflammation
Background:
- Exhaled nitric oxide (NO) is a marker of airway inflammation.
- Chronic bronchitis and asthma are inflammatory airway diseases with distinct pathologies.
- Chronic Obstructive Pulmonary Disease (COPD) also involves airway inflammation.
Purpose of the Study:
- To investigate elevated exhaled nitric oxide (NO) in chronic bronchitis patients.
- To compare exhaled NO levels in chronic bronchitis, asthma, and COPD.
- To identify potential common inflammatory markers between these respiratory conditions.
Main Methods:
- A cross-sectional survey design was employed.
- 179 patients with chronic bronchitis, asthma, or COPD were recruited.
- Exhaled nitric oxide was measured using chemiluminescence with a single-breath technique.
Main Results:
- Exhaled NO was significantly higher in non-smokers with chronic bronchitis (17.0 ± 1.1 ppb) and asthma (16.4 ± 1.3 ppb) compared to controls.
- Patients with both chronic bronchitis and asthma exhibited the highest exhaled NO levels (20.2 ± 1.6 ppb).
- No significant increase in exhaled NO was found in patients with COPD (14.7 ± 1.0 ppb).
Conclusions:
- Exhaled nitric oxide is elevated in chronic bronchitis, similar to asthma.
- The highest exhaled NO concentrations were observed in patients with co-existing chronic bronchitis and asthma.
- Increased exhaled NO in these conditions suggests common underlying inflammatory processes despite distinct histopathology.
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