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[ACE gene polymorphism and cardiovascular diseases].
1Klinik und Poliklinik für Innere Medizin II, Universität Regensburg.
Herz
|March 14, 2000
Summary
The angiotensin converting enzyme (ACE) gene polymorphism influences serum ACE activity and is linked to cardiovascular diseases like hypertension and myocardial infarction.
Area of Science:
- Biochemistry
- Genetics
- Cardiovascular Science
Context:
- The angiotensin converting enzyme (ACE) is crucial for metabolizing vasoactive peptides.
- ACE is induced in conditions such as myocardial infarction and left ventricular hypertrophy.
- A deletion/insertion (D/I) polymorphism in the human ACE gene affects enzyme activity.
Purpose:
- To explore the role of ACE in cardiovascular pathophysiology.
- To investigate the association between ACE gene polymorphism and cardiovascular disorders.
Summary:
- The angiotensin converting enzyme (ACE) plays a key role in the renin-angiotensin system and bradykinin metabolism.
- Experimental evidence shows ACE is upregulated in pathophysiological states like myocardial infarction.
- A common deletion/insertion (D/I) polymorphism in the ACE gene explains significant interindividual variation in serum ACE levels.
Impact:
- The ACE (D/I) polymorphism is implicated in the pathogenesis of cardiovascular diseases.
- Understanding this polymorphism aids in predicting susceptibility to hypertension, myocardial infarction, and nephropathy.
- This genetic marker offers insights into personalized medicine approaches for cardiovascular risk management.