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[Some hemorheological factors in patients with cerebrovascular ischemia]
C E Scherle-Matamoros1, A Nasiff-Hadad, J Pérez-Nellar
1Servicio de Neurología, Hospital Clínico Quirúrgico Hermanos Ameijeiras, La Habana, Cuba. csm@infomed.sld.cu
Insights
Patients with ischemic cerebrovascular disease exhibit elevated blood viscosity and plasma fibrinogen. These hemorheological factors are key indicators in understanding stroke pathology beyond embolic causes.
Area of Science:
- Neurology
- Hematology
- Vascular Medicine
Context:
- Ischemic cerebrovascular disease (ICVD) poses a significant health burden.
- Understanding non-embolic causes of ICVD is crucial for targeted therapies.
- Hemorheological factors play a role in microcirculation and macrocirculation disruptions.
Purpose:
- To investigate hemorheological differences in patients with non-embolic ischemic cerebrovascular disease compared to controls.
- To explore specific hemorheological alterations in different subtypes of ICVD (large vessel disease vs. lacunar infarcts).
Summary:
- Forty ICVD patients and forty controls were studied.
- Blood viscosity and plasma fibrinogen were significantly higher in ICVD patients.
- Hematocrit levels were comparable across all groups, and no significant differences in viscosity or fibrinogen were observed between large vessel disease and lacunar infarct groups.
Impact:
- Highlights elevated blood viscosity and fibrinogen as potential biomarkers for non-embolic ICVD.
- Suggests that hemorheological profiles may not differentiate between major vascular alterations and lacunar infarcts.
- Provides insights into the pathophysiological mechanisms of ischemic stroke.
Introduction And Objective:
To study hemorheological factors in patients with ischemic cerebrovascular disease (not secondary to embolic cardiopathy).
Patients And Methods:
We assessed 40 patients with an average age of 64.5 years; 26 had cerebral infarcts due to alterations in major blood vessels and 14 had lacunar infarcts. Forty persons with no cerebrovascular disease acted as controls. The hematological studies were done between three weeks and six months after the initial ictus.
Results:
Blood viscosity and plasma fibrinogen concentrations were significantly higher in the patients than in the controls. However, hematocrit values were similar in all three groups studied. With regard to the hematocrit, fibrinogen levels and blood viscosity, no differences were seen between the group with damage to the great vessels and those with lacunar infarcts.