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Antibody against a novel, myriocin (ISP-I)-based immunosuppressant, FTY720
T Fujita1, N Matsumoto, S Uchida
1Faculty of Pharmaceutical Sciences, Setsunan University, Osaka, Japan. fujita@pharm.setsunan.ac.jp
Bioorganic & Medicinal Chemistry Letters
|March 14, 2000
Abstract:
An antibody was prepared by immunizing rabbits with an ovalbumin conjugate of 2-amino-2-(2-(4-(4-mercaptobutyl)phenyl)ethyl)propane-1,3-diol HCl (AMPD-4), which contains the essential structure of the novel immunosuppressant FTY720. As the antibody reacted to not only AMPD-4, but also FTY720, it should be useful for immunoassay of FTY720 in body fluids, tissues and cells.