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Augmentation strategies in depression 2000.

J C Nelson1

  • 1Department of Psychiatry, Yale University School of Medicine, New Haven, Conn 06520-8037, USA.

The Journal of Clinical Psychiatry
|March 14, 2000
PubMed
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Combination treatments and augmentation strategies are popular for refractory depression, improving response rates and speed. This review examines evidence, administration, and pros and cons of these advanced therapeutic approaches.

Area of Science:

  • Neuroscience
  • Psychiatry
  • Pharmacology

Background:

  • Refractory depression requires advanced treatment strategies.
  • Partial responders benefit from enhanced therapeutic interventions.
  • Augmentation and combination treatments are increasingly utilized.

Purpose of the Study:

  • To review evidence supporting augmentation and combination treatments for depression.
  • To discuss administration methods for these strategies.
  • To consider the advantages and disadvantages of combined therapeutic approaches.

Main Methods:

  • Literature review of augmentation and combination treatments.
  • Analysis of administration routes and protocols.
  • Comparative assessment of treatment efficacy and safety.

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Main Results:

  • Evidence supports improved therapeutic response in refractory depression.
  • Combination therapies can accelerate treatment outcomes.
  • Administration methods vary, impacting efficacy and tolerability.

Conclusions:

  • Augmentation and combination treatments offer viable options for difficult-to-treat depression.
  • Careful consideration of evidence, administration, and comparative risks is crucial.
  • These strategies enhance treatment response for a significant patient subset.