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Insulin receptors in the brain cortex of aging mice
1Gerontologic Research Department, Center of Biochemistry, INRCA, Ancona, Italy.
Mechanisms of Ageing and Development
|March 14, 2000
Abstract:
The aim of the present study was to analyze whether aging also affects central insulin receptors in brain cortex as it does in whole brain of BALB/c-nu mice. Results showed statistically significant decrease of number and increase of affinity of insulin high affinity binding sites in old animals. As a consequence, central insulin actions, among which neuromodulation of monoaminergic system, can result altered during aging.