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Related Experiment Videos

Do biocides select for antibiotic resistance?

A D Russell1

  • 1Welsh School of Pharmacy, Cardiff University. russellD2@cardiff.ac.uk

The Journal of Pharmacy and Pharmacology
|March 14, 2000
PubMed
Summary
This summary is machine-generated.

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Bacterial resistance to antibiotics and biocides shows similarities. Gram-negative bacteria resistant to biocides may also resist antibiotics, possibly due to outer membrane changes or efflux mechanisms.

Area of Science:

  • Microbiology
  • Molecular Biology
  • Antimicrobial Resistance

Background:

  • Similarities exist between bacterial resistance to antibiotics and biocides.
  • Gram-negative bacteria resistant to cationic biocides may exhibit reduced susceptibility to certain antibiotics.
  • Mechanisms like outer membrane changes and efflux pumps (e.g., qacA/B in staphylococci) are implicated in cross-resistance.

Purpose of the Study:

  • To explore the relationship between bacterial resistance to biocides and antibiotics.
  • To investigate the role of specific resistance mechanisms in cross-resistance.
  • To evaluate the clinical implications of biocide use on antibiotic resistance selection.

Main Methods:

  • Review of existing literature on bacterial resistance mechanisms.

Related Experiment Videos

  • Analysis of studies investigating outer membrane modifications and efflux systems.
  • Examination of proposed links between biocide exposure and antibiotic resistance in bacteria like E. coli and staphylococci.

    • Main Results:

    • Outer membrane alterations are a proposed cause for non-specific resistance increases in gram-negative bacteria.
    • The qacA/B gene system in staphylococci confers low-level resistance to biocides like chlorhexidine and quaternary ammonium compounds.
    • A potential link between low-level triclosan resistance and chromosomally-mediated antibiotic resistance in E. coli has been suggested.

    Conclusions:

    • The clinical relevance of low-level biocide resistance in selecting for antibiotic-resistant bacteria requires further investigation.
    • The concentrations of biocides used in some studies may not reflect clinical settings, impacting resistance selection findings.
    • Understanding cross-resistance mechanisms is crucial for managing both biocide and antibiotic resistance.