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Brain atrophy in relapsing-remitting multiple sclerosis and secondary progressive multiple sclerosis: longitudinal
Y Ge1, R I Grossman, J K Udupa
1Department of Radiology, Hospital of the University of Pennsylvania, Founders, Philadelphia 19104-4283, USA.
Radiology
|March 14, 2000
Summary
Brain atrophy progresses faster in secondary progressive multiple sclerosis (MS) than relapsing-remitting MS. Brain volume loss correlates with disability in SPMS but not RRMS.
Area of Science:
- Neuroimaging
- Neurology
- Medical Research
Background:
- Multiple sclerosis (MS) is a chronic neurological disease.
- Understanding brain volume changes is crucial for MS progression assessment.
Purpose of the Study:
- To quantify annual brain parenchyma volume changes in relapsing-remitting MS (RRMS) and secondary progressive MS (SPMS).
- To investigate the correlation between brain atrophy and clinical disability (EDSS).
Main Methods:
- Utilized computer-assisted segmentation with thin-section magnetic resonance (MR) imaging.
- Calculated percentage brain parenchyma volume (PBV) in 36 MS patients and 20 controls.
- Assessed brain and cerebrospinal fluid volumes.
Main Results:
- MS patients had lower initial PBV compared to controls.
- Median brain volume loss was 17.3 mL/year (RRMS) and 23.6 mL/year (SPMS).
- Significant negative correlation between brain atrophy and EDSS in SPMS (r = -0.69, P = .004), but not in RRMS.
Conclusions:
- Brain atrophy is more pronounced in SPMS than RRMS.
- Clinical disability (EDSS) correlates with brain atrophy in SPMS, but not RRMS.