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Related Experiment Videos

Apparent ipsilateral decrease in breast size at mammography: a sign of infiltrating lobular carcinoma.

J A Harvey1, R E Fechner, M M Moore

  • 1Department of Radiology, University of Virginia, Charlottesville 22908, USA.

Radiology
|March 14, 2000
PubMed
Summary
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An apparent decrease in mammographic breast size may indicate infiltrating lobular carcinoma (ILC). This finding, particularly when combined with clinical breast thickening and mammographic asymmetry, can aid in ILC detection.

Area of Science:

  • Radiology
  • Oncology
  • Breast Imaging

Background:

  • Infiltrating lobular carcinoma (ILC) is the second most common type of invasive breast cancer.
  • Mammographic changes can be subtle in ILC, making diagnosis challenging.

Purpose of the Study:

  • To investigate the association between infiltrating lobular carcinoma (ILC) and a decrease in ipsilateral mammographic breast size.
  • To identify imaging and clinical features that may help detect ILC based on mammographic size changes.

Main Methods:

  • Retrospective review of 30 patients diagnosed with ILC.
  • Measurement of mammographic breast size using nipple-to-pectoralis muscle distance on mediolateral oblique views.
  • Correlation of mammographic findings with clinical and histopathologic data.

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Main Results:

  • 17% of patients with ILC showed an ipsilateral decrease in mammographic breast size.
  • This size decrease was associated with clinical breast thickening (80%) and mammographic focal asymmetry or architectural distortion.
  • Tumors associated with size decrease were larger (mean 66 mm vs. 16 mm) and showed more diffuse infiltration histologically.

Conclusions:

  • A decrease in mammographic breast size can be an indicator of ILC.
  • The combination of clinical breast thickening and mammographic focal asymmetric density alongside size decrease may improve ILC identification.