Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Warfarin-induced skin necrosis.

A J Stewart1, I D Penman, M K Cook

  • 1Department of Haematology, St John's Hospital at Howden, Livingston, West Lothian, UK.

Postgraduate Medical Journal
|March 15, 2000
PubMed
Summary

Warfarin treatment can cause rare skin necrosis, especially in patients with thrombophilic conditions and rapid dose increases. Prompt action is crucial to prevent permanent tissue damage if this side effect occurs.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Survey describing the perspectives and practices of Australian veterinarians to pain management in horses.

Australian veterinary journal·2026
Same author

Radiobiology and modelling in Brachytherapy: A review inspired by the ESTRO Brachytherapy pre-meeting course.

Clinical and translational radiation oncology·2024
Same author

The Royal College of Radiologists National Vulvar Cancer Audit.

Clinical oncology (Royal College of Radiologists (Great Britain))·2024
Same author

Screening for atrial fibrillation in care homes using pulse palpation and the AliveCor Kardia Mobile® device: a comparative cross-sectional pilot study.

International journal of clinical pharmacy·2023
Same author

Evaluation of field-testing protocols to diagnose insulin dysregulation in ponies using a Bayesian approach.

Veterinary journal (London, England : 1997)·2023
Same author

Investigation of breed differences in plasma adrenocorticotropic hormone concentrations among healthy horses and ponies.

Veterinary journal (London, England : 1997)·2023

Area of Science:

  • Cardiology
  • Hematology
  • Dermatology

Background:

  • Warfarin is a widely used anticoagulant medication.
  • Skin necrosis is a rare but severe adverse effect associated with warfarin therapy.
  • Thrombophilic abnormalities increase the risk of warfarin-induced skin necrosis.

Observation:

  • Rapid warfarinization with large loading doses poses a higher risk.
  • Increasing numbers of out-patients receiving anticoagulation for thromboprophylaxis may lead to a higher incidence.
  • Early recognition and intervention are key to managing this complication.

Findings:

  • Patients with thrombophilic conditions are particularly susceptible to warfarin-induced skin necrosis.
  • Aggressive initial dosing of warfarin exacerbates the risk.
  • The rising use of outpatient anticoagulation necessitates awareness of this adverse event.

Implications:

  • Healthcare providers should carefully consider dosing strategies in at-risk patients.
  • Vigilance for skin necrosis is essential during warfarin therapy, especially in specific patient populations.
  • Prompt medical intervention can mitigate the severity and prevent long-term consequences of warfarin-induced skin necrosis.

Related Experiment Videos