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Updated: Oct 17, 2026

Detection of Low Copy Number Integrated Viral DNA Formed by In Vitro Hepatitis B Infection
Published on: November 7, 2018
[HBV transmission from father to foetus and HBV DNA in tissues outside the liver]
Objective:
To study the possibility of HBV Transmission from father to foetus and HBV DNA in tissues outside liver.
Methods:
Paired sera were from 8 HBV man carriers whose wives were negative for HBVM and 8 foetuses who were infected with HBV in the womb. S gene nt 451-660 nucleotide, C gene nt 2,022-2,321 nucleotide were directly sequenced.
Results:
The homology of HBV sequence between father and foetus was very high. The mutations of 491, 494, 530, 546 and 581 nucleotide in the S gene caused 113, 114, 126, 131 and 143 amino acid substitution. HBV DNA can be detected in the tissues outside liver of foetus.
Conclusion:
HBV transmission from father to foetus may be present. HBV DNA in tissues outside liver of foetus can be detected.
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