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[Gastroduodenal mucosal morphological changes in tuberculosis-infected children]
Insights
Tuberculosis infection in children significantly increases the risk of Helicobacter infection and gastritis. The longer the tuberculosis infection lasts, the more severe the gastric issues become, impacting overall stomach health.
Area of Science:
- Pediatric Gastroenterology
- Infectious Diseases
- Microbiology
Background:
- Dyspepsia is a common complaint in children.
- Tuberculosis (TB) is a significant global health concern.
- The relationship between TB infection and upper gastrointestinal issues like Helicobacter infection and gastritis in pediatric populations requires further elucidation.
Purpose of the Study:
- To investigate the prevalence and characteristics of Helicobacter infection and gastritis in children with varying durations of tuberculous infection.
- To compare these findings with a control group of children without tuberculous infection.
Main Methods:
- Esophagoduodenoscopy and biopsy were performed on three groups of children (aged 4-14 years): 31 without TB, 30 with recent TB, and 35 with TB for over one year.
- Histopathological examination of biopsies to identify Helicobacter pylori and assess gastritis.
Main Results:
- Children with tuberculous infection exhibited a higher incidence of Helicobacter infection and gastritis compared to those without TB.
- The incidence and severity of these conditions were directly correlated with the duration of tuberculous infection.
- Specific features of chronic gastritis in infected children included widespread gastric mucosal lesions, pronounced antral changes, neutrophilic infiltration, and co-infection with Candida.
Conclusions:
- Tuberculous infection is associated with an increased risk of Helicobacter infection and chronic gastritis in children.
- The duration of tuberculous infection is a critical factor influencing the development and severity of these gastrointestinal conditions.
- These findings highlight the importance of considering gastrointestinal health in pediatric patients with tuberculosis.
Abstract:
Three groups of children aged 4 to 14 years who complained of having dyspepsia were examined. Group 1 included 31 children without tuberculous infection; Group 2 comprised 30 newly tuberculosis-infected children; Group 3 consisted of 35 children who had an over one-year history of the infection. Esophagoduodenoscopy and biopsy indicated that the incidence of Helicobacter infection and gastritis was higher in children with tuberculous infection than in those without it and it was directly related to the duration of infection. The specific features of chronic gastritis in the infected children were the totality of gastric mucous lesion with more profound antral changes, the predominance of progressive gastritis, as appeared as neutrophilic infiltration, gastric mucous contamination with Helicobacter and Candida, and metaplasia.