Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Asian paralysis syndrome.

M A Phadke1, P S Gambhir, A S Deshpande

  • 1Department of Pediatrics, B.J. Medical College, Pune, India. bjmcpune@vsnl.com

Annals of Tropical Paediatrics
|March 15, 2000
PubMed
Summary

A new disease, Asian paralysis syndrome, causes acute flaccid paralysis in children. It differs from Guillain-Barré syndrome and polio, presenting unique diagnostic challenges for public health.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Emerging protein sequencing technologies: proteomics without mass spectrometry?

Expert review of proteomics·2025
Same author

Abundance, diversity, and host assignment of total, intracellular, and extracellular antibiotic resistance genes in riverbed sediments.

Water research·2022
Same author

Nitrogen-doped graphene-like carbon nanosheets from commercial glue: morphology, phase evolution and Li-ion battery performance.

Dalton transactions (Cambridge, England : 2003)·2018
Same author

A comparative clinical study to assess safety and reactogenicity of a DTwP-HepB+Hib vaccine.

Human vaccines & immunotherapeutics·2015
Same author

Evaluation of various laboratory assays in detection of heparin-induced thrombocytopenia in an adult general ICU.

International journal of laboratory hematology·2012
Same author

Stability indicating HPLC method for simultaneous determination of mephenesin and diclofenac diethylamine.

Indian journal of pharmaceutical sciences·2010

Area of Science:

  • Neurology
  • Pediatrics
  • Infectious Disease Epidemiology

Background:

  • Acute flaccid paralysis (AFP) in children necessitates differentiation from various neurological disorders.
  • Poliomyelitis eradication efforts highlight the importance of identifying non-polio causes of AFP.
  • Asian paralysis syndrome, a distinct neurological entity, presents challenges in diagnosis, particularly in regions targeting polio elimination.

Purpose of the Study:

  • To describe a series of pediatric cases presenting with acute flaccid paralysis.
  • To differentiate this new syndrome from Guillain-Barré syndrome (GBS) and poliomyelitis based on clinical and electrophysiological findings.
  • To underscore the public health significance of recognizing Asian paralysis syndrome in the context of polio eradication.

Main Methods:

  • Clinical case series of 20 children admitted with acute flaccid paralysis.
  • Neurological examination to assess paralysis symmetry, bulbar involvement, and sensory changes.
  • Nerve conduction studies to evaluate neuropathy type (axonal vs. demyelinating) and identify anterior horn cell disease.

Main Results:

  • All 20 children presented with bilaterally symmetrical acute flaccid paralysis; 8 had bulbar involvement.
  • Nerve conduction studies indicated motor axonal neuropathy.
  • Partial recovery was observed in affected children.
  • Key differences were noted compared to Guillain-Barré syndrome (sensory involvement, demyelination, 90% recovery) and poliomyelitis (asymmetrical paralysis, muscle spasms, prodromal symptoms, anterior horn cell disease).

Conclusions:

  • Asian paralysis syndrome is a distinct neurological entity characterized by symmetrical motor axonal neuropathy and partial recovery.
  • Accurate differentiation from Guillain-Barré syndrome and poliomyelitis is crucial for appropriate patient management and public health surveillance.
  • This syndrome, prevalent in Asian populations, poses a significant challenge to polio eradication programs due to its similar presentation to poliomyelitis.

Related Experiment Videos