The use of melatonin: an information paper
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Updated: Oct 17, 2026

Human Primary Trophoblast Cell Culture Model to Study the Protective Effects of Melatonin Against Hypoxia/reoxygenation-induced Disruption
Published on: July 30, 2016
1US Army Aeromedical Research Laboratory, Fort Rucker, AL. Lynn.Caldwell@AMEDD.army.mil
Abstract:
The use of melatonin has been a topic of debate for the past several years. Patients frequently ask their physicians about its use, and many physicians are at a loss about what to tell them. Aviators who have trouble sleeping may choose to buy melatonin and use it since it is a "natural" substance. However, they may lack proper education about its use and the issues of concern. Flight surgeons can help educate their patients in the use of melatonin. This paper will briefly discuss the role of melatonin in humans, its effects on circadian rhythms, its sleep-inducing properties, its effects on mood and performance, and issues pertaining to safety. Flight surgeons and other physicians cannot "prescribe" melatonin, but they at least can offer information about its effects and what is not known about melatonin at this time to the aviators who may ask questions concerning this product.
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