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Increased bone turnover in epileptic patients treated with carbamazepine
A Verrotti1, R Greco, G Morgese
1Department of Medicine, University of Chieti, Italy.
Annals of Neurology
|March 15, 2000
Abstract:
Bone turnover has been investigated in 12 epileptic patients before and after treatment with carbamazepine and in 15 sex- and age-matched control subjects. We found higher values of markers of bone formation (serum bone alkaline phosphatase, osteocalcin, and propeptides of types I and III procollagen) and of bone resorption (serum telopeptide of type I collagen and urine N-telopeptides of type I collagen) in patients than in controls. Our study demonstrates that carbamazepine induces an increase of bone turnover.