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An experimental study on systemic inflammatory response syndrome induced by subeschar tissue fluid
1Burn Unit, Nanfang Hospital, First Military Medical University, Guang Zhou, People's Republic of China.
Summary
Subeschar tissue fluid (STF) triggers systemic inflammatory response syndrome (SIRS) by activating macrophages and causing organ damage. This study explores STF
Area of Science:
- Burn injury research
- Inflammation and immunology
- Critical care medicine
Background:
- Systemic inflammatory response syndrome (SIRS) and multiple organ dysfunction syndrome (MODS) are severe complications following burns.
- Subeschar tissue fluid (STF) is a byproduct of burn eschar, but its role in SIRS pathogenesis is not fully understood.
Purpose of the Study:
- To investigate the biological activity of subeschar tissue fluid (STF).
- To elucidate the probable mechanism of STF in the genesis of systemic inflammatory response syndrome (SIRS).
Main Methods:
- Animal models were injected with STF to observe physiological changes.
- Heart rate (HR), respiratory rate (RR), and white blood cell count (WBCC) were monitored.
- Major organ function and inflammatory mediators (TNF-alpha, IL-1) in macrophages exposed to STF were assayed.
Main Results:
- STF injection led to elevated HR, RR, and WBCC in animals.
- STF demonstrated detrimental effects on the function and structure of major visceral organs.
- Macrophages exposed to STF produced excessive levels of TNF-alpha and IL-1, indicating inflammatory activation.
Conclusions:
- Subeschar tissue fluid (STF) is implicated as an inducing factor in the development of SIRS.
- STF may contribute to the pathogenesis of multiple organ dysfunction syndrome (MODS) in the early postburn period.