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The effect on blood pressure of beta-adrenoreceptor-blocking drugs given once daily
Clinical Science and Molecular Medicine. Supplement
|December 1, 1976
Insights
Blood pressure control was similar with once or thrice-daily dosing of propranolol or pindolol. The blood pressure-lowering effects of these beta-receptor blocking drugs lasted 36-48 hours after stopping administration.
Area of Science:
- Pharmacology
- Cardiovascular Medicine
- Clinical Therapeutics
Background:
- Beta-receptor blocking drugs are widely used for hypertension management.
- Understanding optimal dosing frequency and duration of action is crucial for effective treatment.
Purpose of the Study:
- To compare the efficacy of once versus thrice-daily dosing of propranolol and pindolol in blood pressure control.
- To determine the duration of the antihypertensive effect after cessation of these beta-blockers.
Main Methods:
- A comparative study involving patients with hypertension.
- Administration of propranolol and pindolol at different frequencies.
- Monitoring of blood pressure control and assessment of drug washout period.
Main Results:
- Blood pressure was equally controlled irrespective of whether propranolol or pindolol was administered once or three times daily.
- The antihypertensive action of both beta-receptor blocking drugs persisted for 36 to 48 hours following discontinuation of administration.
Conclusions:
- Once-daily dosing of propranolol and pindolol is as effective as thrice-daily dosing for blood pressure control.
- Beta-receptor blocking drugs exhibit a prolonged duration of action, with effects lasting up to 48 hours after cessation.
Abstract:
1. Blood pressure was controlled to the same extent whether propranolol or pindolol was given once or three times/day. 2. The anti-hypertensive action of beta-receptor-blocking drugs persisted for 36-48 h when administration ceased.