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Benign prognosis in idiopathic hyper-CK-emia.
J C Reijneveld1, N C Notermans, W H Linssen
1Department of Neurology - G03.228, Utrecht University Medical Center, 3508 GA, Utrecht, The Netherlands. jreijnev@neuro.azu.nl
Muscle & Nerve
|March 15, 2000
Summary
Long-term follow-up of idiopathic hyper-CK-emia patients shows no clinical deterioration. Routine monitoring is likely unnecessary for these individuals, simplifying their care.
Area of Science:
- Neurology
- Clinical Medicine
- Muscle Disorders
Background:
- Idiopathic hyper-CK-emia is characterized by elevated serum creatine kinase levels without a clear underlying cause.
- Understanding the long-term prognosis and clinical course is crucial for patient management.
Purpose of the Study:
- To evaluate the long-term clinical outcomes in patients diagnosed with idiopathic hyper-CK-emia.
- To determine if routine follow-up is warranted for individuals with this condition.
Main Methods:
- A cohort of 31 patients with idiopathic hyper-CK-emia underwent initial neurological assessment, muscle biopsy, and electromyography (EMG).
- A final evaluation was conducted after a mean follow-up period of 7.2 years (range 4-18 years) on 74% of the cohort.
Main Results:
- The most frequent initial complaints were fatigue and myalgia.
- Muscle biopsy and EMG revealed minor, non-diagnostic abnormalities in a significant proportion of patients.
- At long-term follow-up, patient complaints remained largely unchanged, with no substantial clinical deterioration observed in most cases.
Conclusions:
- Long-term follow-up of idiopathic hyper-CK-emia does not indicate significant clinical deterioration.
- Routine long-term follow-up for patients with idiopathic hyper-CK-emia may not be necessary, potentially reducing healthcare burden.