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Updated: Aug 19, 2026

Receptor Autoradiography Protocol for the Localized Visualization of Angiotensin II Receptors
Published on: June 7, 2016
beta-receptor-blockade hypotension and the central nervous system
Abstract:
1. Intravenous infusion of propranolol (3-86 micronmol h-1 kg-1) for 2 h lowered arterial pressure in the conscious rabbit whereas similar infusions of practolol (37-6 micronmol h-1 kg-1) did not. 2. The fall in blood pressure produced by propranolol was accompanied by a decrease in splanchnic nerve activity. Practolol did not change splanchnic nerve activity. 3. A centrally mediated decrease in sympathetic nervous activity makes an important contribution to the hypotensive action of propranolol in the rabbit. This effect is not shown by practolol.
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