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Thrombolysis by ultrasound
Clinical Science and Molecular Medicine. Supplement
|December 1, 1976
Summary
This study introduces an innovative ultrasound-based method for dissolving and removing blood clots (thrombi) in canine models. The novel technique efficiently cleared thrombi in minutes with no observed adverse effects on blood vessels.
Area of Science:
- Vascular Surgery
- Medical Ultrasound Technology
- Thrombosis Treatment
Background:
- Thrombi in blood vessels pose significant health risks.
- Existing treatments for thrombi can be invasive or have limitations.
Purpose of the Study:
- To report a novel method for destroying and removing thrombi using ultrasound.
- To evaluate the efficacy and safety of this new ultrasound-assisted thrombectomy technique.
Main Methods:
- Experiments conducted on twenty dogs with artificial thrombi in iliac and femoral arteries/veins (4-5 cm length, 12h-10 days old).
- Utilized an ultrasound unit (26-5 kHz frequency, 25-30 micronm amplitude) with a hollow waveguide and vacuum pump for thrombus destruction and aspiration.
- A protective plastic tube surrounded the guide to safeguard the vessel wall.
Main Results:
- The ultrasound method successfully destroyed and removed thrombi in 2.5 to 5 minutes.
- Experiments on forty-four dogs to assess side effects showed no significant changes in the fibrinolytic system.
- Microscopic examination revealed no adverse structural changes in the vessel wall post-ultrasound treatment.
Conclusions:
- Ultrasound-assisted thrombectomy is a rapid and effective method for thrombus removal.
- The technique demonstrated a favorable safety profile, with no significant damage to the vessel wall or systemic effects observed.