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Updated: Aug 14, 2026

Flow-sorting and Exome Sequencing of the Reed-Sternberg Cells of Classical Hodgkin Lymphoma
08:53

Flow-sorting and Exome Sequencing of the Reed-Sternberg Cells of Classical Hodgkin Lymphoma

Published on: June 10, 2017

The Pathology of Hodgkin's Disease: What's New?

Ferry1, Harris

  • 1James Homer Wright Pathology Laboratories of the Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA

Seminars in Radiation Oncology
|July 1, 1996
PubMed

Insights

Pathologists face challenges in diagnosing Hodgkin's disease (HD), identifying prognostic factors, and defining the neoplastic cell. Recent studies reveal Reed-Sternberg cells in HD are often of lymphoid origin, blurring lines with non-Hodgkin's lymphoma.

Area of Science:

  • Pathology
  • Hematology
  • Oncology

Background:

  • Hodgkin's disease (HD) diagnosis involves correct identification, prognostic factors, and neoplastic cell origin.
  • The origin of Reed-Sternberg cells and HD pathogenesis remain areas of investigation.
  • Distinguishing HD from non-Hodgkin's lymphoma can be challenging.

Purpose of the Study:

  • To review the diagnostic challenges in Hodgkin's disease from a pathologist's perspective.
  • To discuss the identity and origin of the neoplastic cell in Hodgkin's disease.
  • To evaluate the role of immunophenotype and genotype in understanding Hodgkin's disease.

Main Methods:

  • Review of diagnostic criteria for Hodgkin's disease.
  • Analysis of immunophenotypic and genotypic data of Reed-Sternberg cells.
  • Comparison of Hodgkin's disease with non-Hodgkin's lymphoma.

Main Results:

  • Reed-Sternberg cells in many Hodgkin's disease cases are of lymphoid origin.
  • The distinction between Hodgkin's disease and non-Hodgkin's lymphoma is less clear than previously thought.
  • Despite overlap, fundamental differences persist in clinical, histological, immunophenotypic, and genotypic features.

Conclusions:

  • Accurate diagnosis of Hodgkin's disease remains crucial.
  • Understanding the lymphoid origin of Reed-Sternberg cells refines diagnostic approaches.
  • While diagnostic challenges exist, key distinctions between Hodgkin's disease and non-Hodgkin's lymphoma are maintained.

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