Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

A functional significance for codon third bases.

R J Epstein1, K Lin, T W Tan

  • 1Imperial College School of Medicine, London, UK.

Gene
|March 16, 2000
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Inclusive Search for Anomalous Single-Photon Production in MicroBooNE.

Physical review letters·2026
Same author

First Search for Dark Sector e^{+}e^{-} Explanations of the MiniBooNE Anomaly at MicroBooNE.

Physical review letters·2026
Same author

Determinants and long-term outcomes of treatment delays in young and middle-aged acute ischemic stroke patients: a prospective cohort study.

BMC neurology·2026
Same author

First Measurement of Charged-Current Muon-Neutrino-Induced K^{+} Production on Argon Using the MicroBooNE Detector.

Physical review letters·2026
Same author

Search for an Anomalous Production of Charged-Current ν_{e} Interactions without Visible Pions across Multiple Kinematic Observables in MicroBooNE.

Physical review letters·2025
Same author

First Measurement of ν_{e} and ν[over ¯]_{e} Charged-Current Single Charged-Pion Production Differential Cross Sections on Argon Using the MicroBooNE Detector.

Physical review letters·2025
Same journal

TBX6 promotes proliferation, invasion, and migration in colorectal cancer: Integrated transcriptomic and protein interaction network analysis.

Gene·2026
Same journal

Face/off: phase-specific modeling of lineage plasticity using near-patient models in genitourinary cancers.

Gene·2026
Same journal

Hierarchical analysis of metabolic phenotype reveals distinct microbiota and circulatory transcriptome in metabolic dysfunction-associated steatotic liver disease.

Gene·2026
Same journal

Mutation T71R enhanced the structural stability and functional activity of wild type superoxide dismutase cloned from soil metagenome.

Gene·2026
Same journal

Reduced ATXN1 expression as an adverse prognostic indicator in Acute myeloid leukemia.

Gene·2026
Same journal

Constructing regulatory networks of Rubisco post-translational modifications: a novel avenue for engineering environment adaptive plants.

Gene·2026
See all related articles

Synonymous codon usage patterns reveal the functional importance of amino acids. Genes with higher GC content and third-base GC retention indicate greater significance, impacting cell function and survival.

Area of Science:

  • Molecular Biology
  • Genetics
  • Bioinformatics

Background:

  • Most amino acids are encoded by multiple synonymous codons.
  • The functional significance of amino acids can vary greatly.
  • Understanding codon usage bias is crucial for deciphering gene regulation and protein function.

Purpose of the Study:

  • To investigate the relationship between synonymous codon usage patterns and the functional importance of amino acids.
  • To determine if GC content in genes and codon usage correlates with transcriptional and mitogenic significance.
  • To analyze codon variation in human receptor tyrosine kinase genes to identify critical amino acids.

Main Methods:

  • Analysis of synonymous codon usage patterns across different genes.
  • Correlation analysis between GC-rich genes and their transcriptional/mitogenic significance.

Related Experiment Videos

  • Sequence analysis of human receptor tyrosine kinase gene homologs.
  • Comparison of codon usage for functionally important versus neutral amino acids.

    • Main Results:

    • GC-rich genes exhibit higher transcriptional and mitogenic significance compared to AT-rich genes.
    • Third-base GC retention in codons identifies critical amino acids within proteins.
    • Functionally important transmembrane hydrophobic amino acids in receptor tyrosine kinases are preferentially encoded by GC-rich codons.

    Conclusions:

    • Synonymous codon usage patterns can distinguish amino acids of differing functional importance.
    • GC content and third-base GC retention are indicators of critical amino acid roles in cellular function and survival.
    • This finding has implications for understanding gene evolution, protein function, and disease mechanisms.