Related Experiment Videos
Pneumocystis carinii mutations associated with sulfa and sulfone prophylaxis failures in immunocompromised patients
W Armstrong1, S Meshnick, P Kazanjian
1Department of Internal Medicine, University of Michigan, Ann Arbor 48109, USA.
Microbes and Infection
|March 16, 2000
Abstract:
Recent studies have shown that mutations in two amino acid positions of the Pneumocystis carinii dihydropteroate synthase gene are significantly more common in immunocompromised patients with P. carinii pneumonia who fail sulfa or sulfone prophylaxis. This paper reviews the studies that suggest that these mutations may be responsible for some failures of prophylaxis in P. carinii.