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[Radiosurgery for brain metastases].

F Nataf1

  • 1Service de Neurochirurgie, CH Sainte-Anne, 1, rue Cabanis, 75674 Paris Cedex 14, France.

Neuro-Chirurgie
|March 16, 2000
PubMed
Summary
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Radiosurgery offers excellent local control for brain metastases, particularly radioresistant types, improving quality of life. However, it does not significantly extend survival duration but presents a favorable cost-benefit ratio.

Area of Science:

  • Neurosurgery
  • Radiation Oncology

Context:

  • Brain metastases represent a significant clinical challenge.
  • Radiosurgery has emerged as a therapeutic strategy over the past decade.

Purpose:

  • To provide an updated literature review on the state-of-the-art in radiosurgery for brain metastases.
  • To evaluate the efficacy, outcomes, and complications of this treatment modality.

Summary:

  • Radiosurgery utilizes X-rays or gamma-rays with high precision for treating brain metastases, typically in patients with good Karnofsky status and metastases around 20 mm.
  • Common primary sites include lung and breast, with radiosurgery also showing promise for radioresistant tumors like malignant melanoma.
  • While achieving high local control rates (80-100%), survival remains around 11 months, with a 4% complication rate.

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Impact:

  • Radiosurgery demonstrates strong arguments for local control, quality of life, and cost-benefit, especially for radioresistant metastases.
  • Further comparative studies are needed to establish its efficacy against surgery and whole-brain radiotherapy.
  • Ongoing evaluations will refine indications for this advanced therapeutic technique.