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[Chronic hepatitis: indicators of disease activity]
Terapevticheskii Arkhiv
|March 16, 2000
Summary
Chronic hepatitis (CH) activity can be assessed using liver morphology (Knodell index) and alanine aminotransferase (AlAT) levels. The AsAT/AlAT ratio may help identify alcohol abuse in patients with viral or alcoholic liver disease.
Area of Science:
- Hepatology
- Biochemistry
- Pathology
Background:
- Chronic hepatitis (CH) activity assessment is crucial for patient management.
- Morphological data and serum enzyme levels are commonly used indicators.
- Distinguishing viral from alcoholic liver lesions requires reliable markers.
Purpose of the Study:
- To evaluate the correlation between liver morphology and alanine aminotransferase (AlAT) serum levels in CH patients.
- To assess the utility of morphological data and AlAT in viral and alcoholic liver diseases.
- To determine the role of the AsAT/AlAT ratio in identifying alcohol abuse.
Main Methods:
- Histological examination of liver biopsy specimens.
- Biochemical blood tests including AlAT and AsAT levels.
- Serological tests for viral markers.
- Calculation of the Knodell index for morphological assessment.
Main Results:
- A significant correlation was found between the Knodell index and AlAT serum activity.
- Normal Knodell index scores (1-5) may correspond to normal AlAT levels.
- The AsAT/AlAT ratio was elevated in CH patients without viral markers, suggesting alcohol involvement.
Conclusions:
- Morphological data (Knodell index), AlAT, and the AsAT/AlAT ratio are valuable indicators of CH activity.
- The AsAT/AlAT ratio can aid in differentiating alcohol-related liver disease from viral hepatitis.
- Integrated assessment of these markers improves diagnostic accuracy for CH.
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