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[Apudocytes and mast cells in chronic inflammation of colon: clinicomorphological correlations]
Aim:
To study functional morphology of a total population of endocrine cells of colon mucosa, mast and enterochromaffine cells.
Materials And Methods:
Light and electrone microscopy, immunohistochemical methods, morphometry were used to study endocrine and mast cells of the sigmoid colon in inflammation.
Results:
Changes of functional morphology and size of endocrine and mast cell population as well as apudocytes producing serotonin, melatonin, vasointestinal peptides were stated. Apudocyte and mass cell functional morphology, clinical symptoms and mucosal structural changes correlated. Specificity of some parameters in Chron's disease is shown.
Conclusion:
The results may provide additional criteria in diagnosis of different variants of chronic colitis.