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Updated: Oct 17, 2026

11:42
Solid Phase Synthesis of a Functionalized Bis-Peptide Using "Safety Catch" Methodology
Published on: May 15, 2012
Acetophenone-based linker for solid-phase peptide synthesis
1Chiron Technologies Pty. Ltd., Clayton, Victoria, Australia. chinh_thien_bui@cc.chiron.com
Abstract:
A new and cost-effective linker for the generation of carboxylic acid end groups on Multipin supports (SynPhase crowns) has been developed. Synthesis of the linker was based on modification of grafted polystyrene (PS) crowns to generate a hydroxyethyl moiety which is acid labile in 10-20% trifluoroacetic acid (TFA) in dichloromethane (DCM). Solid-phase syntheses of model decapeptides using this linker are described.
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