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Related Concept Videos

Induced Pluripotent Stem Cells01:13

Induced Pluripotent Stem Cells

Stem cells are undifferentiated cells that divide and produce different types of cells. Ordinarily, cells that have differentiated into a specific cell type are post-mitotic—that is, they no longer divide. However, scientists have found a way to reprogram these mature cells so that they “de-differentiate” and return to an unspecialized, proliferative state. These cells are also pluripotent like embryonic stem cells—able to produce all cell types—and are therefore called induced pluripotent stem...
Induced Pluripotent Stem Cells01:13

Induced Pluripotent Stem Cells

Stem cells are undifferentiated cells that divide and produce different types of cells. Ordinarily, cells that have differentiated into a specific cell type are post-mitotic—that is, they no longer divide. However, scientists have found a way to reprogram these mature cells so that they “de-differentiate” and return to an unspecialized, proliferative state. These cells are also pluripotent like embryonic stem cells—able to produce all cell types—and are therefore called induced pluripotent stem...
Stem Cell Culture01:17

Stem Cell Culture

Stem cell research aims to find ways to use stem cells to regenerate and repair cellular damage. Over time, most adult cells undergo the wear and tear of aging and lose their ability to divide and repair themselves. Stem cells do not display a particular morphology or function. Adult stem cells, which exist as a small subset of cells in most tissues, keep dividing and can differentiate into a number of specialized cells generally formed by that tissue. These cells enable the body to renew and...
Induced Pluripotent Stem Cells01:06

Induced Pluripotent Stem Cells

Stem cells are undifferentiated cells that divide and produce different cell types. Ordinarily, cells that have differentiated into a specific cell type are terminally differentiated; however, scientists have found a way to reprogram these mature cells so that they dedifferentiate and return to an unspecialized, proliferative state. These cells are pluripotent like embryonic stem cells—able to produce all cell types—and are called induced pluripotent stem cells (iPSCs).
Somatic cells are...
Somatic to iPS Cell Reprogramming01:29

Somatic to iPS Cell Reprogramming

Reprogramming alters the gene expression in somatic cells, transforming them into induced pluripotent stem (iPS) cells over several generations. Scientists can reprogram cells by introducing genes for four transcription factors—Oct4, Sox2, Klf4, and c-Myc (OSKM) by viral or non-viral methods. These factors are also known as Yamanaka factors after Shinya Yamanaka, who first generated iPS cells using mouse skin cells. Yamanaka was awarded the Nobel Prize in Physiology or Medicine in 2012 for this...
Forced Transdifferentiation01:28

Forced Transdifferentiation

Transdifferentiation, also known as lineage reprogramming, was first discovered by Selman and Kafatos in 1974 in silkmoths. They observed that the moths’ cuticle-producing cells transformed into salt-producing cells. Many such cases of natural transdifferentiation occur in organisms. In humans, pancreatic alpha cells can become beta cells. In newts, the loss of the eye’s lens causes the pigmented epithelial cells to transdifferentiate into the lens cells.
Artificial transdifferentiation occurs...

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Related Experiment Video

Updated: Jul 27, 2026

Establishment of Cancer Stem Cell Cultures from Human Conventional Osteosarcoma
09:25

Establishment of Cancer Stem Cell Cultures from Human Conventional Osteosarcoma

Published on: October 14, 2016

Paradigm shifts in stem-cell biology.

G J Spangrude1, D D Cooper

  • 1Department of Oncological Sciences, University of Utah Medical Center, Salt Lake City 84132, USA.

Seminars in Hematology
|March 16, 2000
PubMed
Summary

Hematopoiesis, the process of blood cell formation, is crucial for treating blood disorders. Recent discoveries in stem cell biology are advancing cell-based therapies for hematologic malignancies and genetic defects.

Area of Science:

  • Hematology
  • Stem Cell Biology
  • Developmental Biology

Background:

  • Hematopoiesis is a vital physiological process involving stem and progenitor cells, crucial for lifelong blood production.
  • These cells are key targets for cell-based therapies addressing hematologic malignancies and genetic disorders.
  • Understanding hematopoiesis is essential for advancing stem cell therapies.

Purpose of the Study:

  • To highlight recent advances in understanding hematopoiesis.
  • To discuss the implications of these advances for stem cell-based therapies.
  • To challenge established concepts in hematopoietic research.

Main Methods:

  • Review of emerging research in hematopoietic stem cell biology.
  • Analysis of new progenitor populations and lineage relationships.

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Reprogramming Mouse Embryonic Fibroblasts with Transcription Factors to Induce a Hemogenic Program
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Reprogramming Mouse Embryonic Fibroblasts with Transcription Factors to Induce a Hemogenic Program

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Reprogramming Induced Pluripotent Stem Cell Lines from Frozen Buffy Coat Samples
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Reprogramming Induced Pluripotent Stem Cell Lines from Frozen Buffy Coat Samples

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Related Experiment Videos

Last Updated: Jul 27, 2026

Establishment of Cancer Stem Cell Cultures from Human Conventional Osteosarcoma
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Establishment of Cancer Stem Cell Cultures from Human Conventional Osteosarcoma

Published on: October 14, 2016

Reprogramming Mouse Embryonic Fibroblasts with Transcription Factors to Induce a Hemogenic Program
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Reprogramming Mouse Embryonic Fibroblasts with Transcription Factors to Induce a Hemogenic Program

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Reprogramming Induced Pluripotent Stem Cell Lines from Frozen Buffy Coat Samples

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  • Reevaluation of the embryonic origins of hematopoiesis.

    • Main Results:

    • An improved understanding of the relationship between cell-cycle status, engraftment, and self-renewal in hematopoietic stem cells.
    • Identification of novel progenitor populations and lineage dynamics during early development.
    • A revised perspective on the embryonic origins of hematopoiesis.

    Conclusions:

    • Recent breakthroughs are rapidly advancing the field of hematopoiesis.
    • These discoveries are paving the way for more effective stem cell therapies.
    • The study of hematopoiesis is unlocking new therapeutic possibilities at an unprecedented pace.