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Urinary tissue factor levels in patients with bladder and prostate cancer
B A Lwaleed1, J L Francis, M Chisholm
1University Department of Haematology, Southampton University Hospitals, UK.
Summary
Urinary tissue factor (uTF) levels can help distinguish malignancy from benign conditions in urological diseases. Elevated uTF also correlates with tumor progression and may predict bladder cancer recurrence.
Area of Science:
- Urology
- Oncology
- Biochemistry
Background:
- Coagulation activation, linked to increased tissue factor (TF), is a known cancer complication.
- Tissue factor (TF) can be detected in urine (uTF).
Purpose of the Study:
- To assess urinary tissue factor (uTF) levels in benign and malignant urological conditions.
- To correlate uTF levels with conventional markers of tumor progression.
Main Methods:
- A kinetic chromogenic assay was used to determine uTF levels.
- Study included healthy volunteers, patients with renal stones, benign or malignant bladder/prostate disease, and recurrent bladder cancer patients.
- Benign disease groups were stratified into inflammatory and non-inflammatory categories.
Main Results:
- Malignant and inflammatory groups exhibited significantly higher uTF levels compared to controls.
- The distinction between malignant and benign inflammatory disease was significant only for bladder conditions.
- uTF levels showed significant associations with tumor grade, PSA, bone scan findings, and recurrence status.
Conclusions:
- Urinary tissue factor (uTF) levels can statistically differentiate malignancy from benign non-inflammatory conditions, though with some overlap.
- Discrimination between inflammatory and malignant disease was demonstrated for bladder conditions.
- uTF levels are associated with tumor progression markers and may aid in predicting bladder tumor recurrence.