Health Utilities Index Mark 3: evidence of construct validity for stroke and arthritis in a population health survey
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Published on: July 14, 2023
P Grootendorst1, D Feeny, W Furlong
1Department of Clinical Epidemiology and Biostatistics, McMaster University, Centre for Evaluation of Medicines, St. Joseph's Hospital, Hamilton, Ontario, Canada. grootend@fhs.mcmaster.ca
Insights
The Health Utilities Index Mark 3 (HUI3) accurately measures health-related quality of life (HRQL) in individuals with arthritis and stroke. This validated tool reflects specific health attribute impacts for these conditions in population health surveys.
Area of Science:
- Health Economics and Outcomes Research
- Epidemiology
- Biostatistics
Background:
- The Health Utilities Index Mark 3 (HUI3) is a widely used system for classifying health status and preferences.
- It has been incorporated into significant Canadian population health surveys and clinical trials.
Purpose of the Study:
- To assess the construct validity of the HUI3 for measuring health-related quality of life (HRQL) and attribute-specific morbidity.
- To evaluate HUI3's ability to detect specific health impacts in individuals with arthritis and stroke.
Main Methods:
- Linear regression models were employed to analyze HRQL and attribute-specific utilities.
- The analysis utilized indicator variables for stroke, arthritis, and co-occurrence of both conditions, controlling for confounding factors.
Main Results:
- Individuals with stroke, arthritis, or both reported significantly lower HRQL compared to those without these conditions.
- Stroke impacted speech and cognition more than arthritis, while pain morbidity was only slightly higher in arthritis patients. Vision and hearing were unaffected by either condition.
- Findings remained consistent across various model specifications, indicating robustness.
Conclusions:
- The HUI3 demonstrates validity in assessing health status and HRQL for stroke and arthritis populations.
- The system is suitable for use in non-institutionalized population health surveys.
Background:
The Health Utilities Index Mark 3 (HUI3) is a comprehensive, compact health status classification and health state preference system. The HUI3 system has been included in 4 Canadian population health surveys and numerous clinical trials.
Objectives:
To evaluate the construct validity of the HUI3 for the measurement of health-related quality of life (HRQL) and attribute-specific morbidity in respondents to the 1990 Ontario Health Survey reported to have arthritis or stroke. The authors assessed (1) whether those with stroke, arthritis, and both conditions had lower HRQL scores than those with neither condition and (2) whether HUI3 detects morbidity in specific health attributes affected by arthritis and stroke. Stroke (but not arthritis) were expected to affect speech and cognition; arthritis (but not stroke) to affect pain; both to affect mobility, dexterity, and emotion; and neither to affect vision and hearing.
Research Design:
Linear regression models of HRQL and attribute-specific utilities were estimated as a function of 3 indicator variables of health problem (stroke only, arthritis only, both) and variables included to reduce confounding.
Results:
Subjects with stroke, arthritis, and both conditions had substantially lower HRQL than those with neither condition. Stroke subjects had greater morbidity in speech and cognition than arthritis subjects; somewhat surprisingly, pain morbidity was only slightly higher among arthritis subjects; neither condition affected vision or hearing. These associations were robust to various model specifications.
Conclusions:
The HUI3 system appears valid for measuring health status and HRQL for stroke and arthritis in the context of a noninstitutionalized population health survey.