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N-myristoyltransferase
R V Rajala1, R S Datla, T N Moyana
1Department of Pathology and Saskatoon Cancer Centre, College of Medicine, Royal University Hospital, University of Saskatchewan, Canada.
Molecular and Cellular Biochemistry
|March 16, 2000
Abstract:
Myristoylation refers to the co-translational addition of a myristoyl group to an amino-terminal glycine residue of a protein by an ubiquitously distributed enzyme myristoyl-CoA:protein N-myristoyltransferase (NMT, EC 2.3.1.97). This review describes the basic enzymology, molecular cloning and regulation of NMT activity in various pathophysiological processes such as colon cancer and diabetes.