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Preprimed artificial lung for emergency use.

E Tatsumi1, Y Taenaka, H Takano

  • 1Department of Artificial Organs, National Cardiovascular Center Research Institute, Osaka, Japan. tatsumi@ri.ncvc.go.jp

Artificial Organs
|March 16, 2000
PubMed
Summary

Preprimed storage of artificial lungs (ALs) using saline and gamma-ray sterilization is feasible for emergency use. While minor bubbles and some material breakdown products were observed, the artificial lung

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Area of Science:

  • Biomedical Engineering
  • Materials Science
  • Medical Devices

Background:

  • Artificial lungs (ALs) require rapid deployment for emergency use.
  • Preprimed storage could significantly reduce setup time in critical situations.

Purpose of the Study:

  • To evaluate the feasibility of preprimed storage for artificial lungs (ALs).
  • To assess the impact of gamma-ray sterilization and storage on AL integrity and function.

Main Methods:

  • Artificial lungs (ALs) with polyolefin hollow fiber membranes were preprimed with saline and sterilized via gamma-ray irradiation.
  • Stored ALs were evaluated after 1-3 months at room temperature.
  • Material properties (tensile stress, elongation) and gas-exchange function in a goat model were assessed.

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Main Results:

  • Minor bubbles and non-toxic levels of polyolefin breakdown products were detected in stored ALs.
  • SEM showed no microstructural changes; however, tensile strength and elongation decreased slightly.
  • Oxygen transfer was preserved, while carbon dioxide removal function showed a slight decrease with storage duration.

Conclusions:

  • Preprimed storage of artificial lungs (ALs) with gamma-ray sterilization is a feasible and realistic approach.
  • The observed changes did not critically impair essential functions for potential emergency applications.