Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Transcytosis of IgG

Transcytosis of IgG

Transcytosis is the process in which molecules are internalized by endocytosis, transported across the cell, and released through exocytosis from the opposite end of the cell. Molecules such as insulin, immunoglobulins, and certain nutrients are transferred through the recycling endosomes by recycling and transcytosis.
IgG molecules from a mother undergo transcytosis starting around 13 weeks of gestation. The amount of IgG transferred and entering the fetal blood circulation increases with...

Development of Immunocompetence

Development of Immunocompetence

The initiation of cell-mediated immunity can be observed as early as the third month of fetal growth, with active antibody-mediated immunity following approximately one month later.
The initial cells that migrate from the fetal thymus settle within the skin and epithelial tissues lining the mouth, digestive tract, and in females, the uterus and vagina. These cells, including skin-based dendritic cells, serve as antigen-presenting cells, playing a key role in T cell activation.
Subsequent T...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Sub2: A TFIIB Interacting Protein with Pleiotropic Roles in mRNA Synthesis, Processing and Transport.

International journal of biochemistry & physiology·2025

Same author

Direct Interaction of Long-Term Reactive Oxygen-Based Species Stored in Microencapsulation of Olive Oil on Burn Scars of Wistar Rats.

ACS applied bio materials·2025

Same author

Frequency of Low Cardiac Output Syndrome Following on Pump Coronary Artery Bypass Grafting Surgery and it's Association with Degree of Pre-operative Left Ventricular Dysfunction.

Kathmandu University medical journal (KUMJ)·2023

Same author

A rare case of pancreatic head hydatid cyst.

QJM : monthly journal of the Association of Physicians·2023

Same author

Design and performance of a double-solenoid magnetic bottle photoelectron spectrometer for attosecond metrology.

The Review of scientific instruments·2023

Same author

Estimation of External Contamination and Exposure Rates Due to Fission Product Release.

Health physics·2020

Search research articles

Related Experiment Video

Updated: Jul 26, 2026

Isolation of Leukocytes from the Human Maternal-fetal Interface

Isolation of Leukocytes from the Human Maternal-fetal Interface

Published on: May 21, 2015

Fetal microchimerisms in the mother: immunologic implications.

A Tanaka¹, K Lindor, A Ansari

¹Division of Rheumatology, Allergy, and Clinical Immunology, University of California at Davis, 95616-8660, USA.

Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society

|March 17, 2000

Summary

Fetal cells can transfer to mothers, causing microchimerism, which may play a role in autoimmune diseases like scleroderma. This fetal cell migration is common and may also aid maternal-fetal tolerance.

More Related Videos

Isolation of Leukocytes from the Murine Tissues at the Maternal-Fetal Interface

Isolation of Leukocytes from the Murine Tissues at the Maternal-Fetal Interface

Published on: May 21, 2015

A Murine Model of Fetal Exposure to Maternal Inflammation to Study the Effects of Acute Chorioamnionitis on Newborn Intestinal Development

A Murine Model of Fetal Exposure to Maternal Inflammation to Study the Effects of Acute Chorioamnionitis on Newborn Intestinal Development

Published on: June 24, 2020

Related Experiment Videos

Last Updated: Jul 26, 2026

Isolation of Leukocytes from the Human Maternal-fetal Interface

Isolation of Leukocytes from the Human Maternal-fetal Interface

Published on: May 21, 2015

Isolation of Leukocytes from the Murine Tissues at the Maternal-Fetal Interface

Isolation of Leukocytes from the Murine Tissues at the Maternal-Fetal Interface

Published on: May 21, 2015

A Murine Model of Fetal Exposure to Maternal Inflammation to Study the Effects of Acute Chorioamnionitis on Newborn Intestinal Development

A Murine Model of Fetal Exposure to Maternal Inflammation to Study the Effects of Acute Chorioamnionitis on Newborn Intestinal Development

Published on: June 24, 2020

Area of Science:

Reproductive Immunology
Immunology
Genetics

Background:

The placenta was traditionally viewed as a barrier, but recent findings show fetal cells can cross into maternal tissues.
Fetal cell microchimerism, the presence of fetal cells in mothers, is increasingly recognized.
The role of microchimerism in maternal health and disease is an emerging area of research.

Purpose of the Study:

To investigate the presence and implications of fetal cell microchimerism in maternal autoimmune diseases.
To explore the potential link between fetal cell migration and the pathogenesis of conditions like scleroderma and primary biliary cirrhosis (PBC).

Main Methods:

Detection of fetal cell-derived DNA in maternal peripheral blood and tissues.
Comparison of microchimerism frequency in patients with autoimmune diseases versus healthy controls.

Main Results:

Fetal DNA was found more frequently in the blood of scleroderma patients than controls, suggesting a role in disease induction.
Microchimerism was common in liver tissues of both PBC patients and controls, indicating it's a frequent event.
The study suggests microchimerism alone may not fully explain PBC pathogenesis.

Conclusions:

Fetal cell microchimerism is a common phenomenon with potential roles in both autoimmune disease pathogenesis and maintaining maternal-fetal tolerance during pregnancy.
While microchimerism may contribute to diseases like scleroderma, its role in PBC appears less direct.
Further research is needed to fully elucidate the complex interactions between fetal cells and maternal immune systems.