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Related Experiment Videos

Lessons from childhood-onset schizophrenia.

R Nicolson1, M Lenane, S D Hamburger

  • 1Child Psychiatry Branch, National Institute of Mental Health, 10 Center Drive MSC 1600, Bethesda, MD, USA.

Brain Research. Brain Research Reviews
|March 17, 2000
PubMed
Summary

Childhood-onset schizophrenia, diagnosed before age 12, shows more genetic vulnerability and fewer environmental factors than adult-onset cases. Early onset schizophrenia may stem from greater genetic predisposition.

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Area of Science:

  • Neuroscience
  • Psychiatry
  • Genetics

Background:

  • Childhood-onset schizophrenia (COS) is a rare, severe disorder continuous with adult-onset schizophrenia.
  • Very early onset diseases offer insights into homogenous patient populations and salient risk factors.

Purpose of the Study:

  • To investigate potential etiologic factors in very early onset schizophrenia (VEOS).
  • To compare characteristics of VEOS with adult-onset schizophrenia.

Main Methods:

  • Retrospective analysis of 47 patients with VEOS.
  • Comparison of neurodevelopmental abnormalities, cytogenetic anomalies, family history, obstetrical complications, and environmental stress between VEOS and later-onset cases.

Main Results:

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  • VEOS patients exhibited more severe premorbid neurodevelopmental abnormalities.
  • Increased cytogenetic anomalies and family histories of schizophrenia spectrum disorders were observed in VEOS.
  • No increased obstetrical complications or environmental stress were found in VEOS.

    • Conclusions:

    • Preliminary data suggest a greater genetic vulnerability in VEOS.
    • Future genetic studies in VEOS patients are anticipated to yield crucial etiologic information.