Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Aging-induced osteopenia in avian cortical bone.

S Srinivasan1, S A Keilin, S Judex

  • 1Department of Orthopaedic Surgery, University of Cincinnati, Cincinnati, OH 45267-0212, USA.

Bone
|March 17, 2000
PubMed
Summary

Aged roosters exhibit significant cortical bone loss, mirroring human aging. This study suggests rooster bone is a valuable model for understanding age-related skeletal degradation.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Locomotor activity, growth hormones, and systemic robusticity: An investigation of cranial vault thickness in mouse lines bred for high endurance running.

American journal of physical anthropology·2018
Same author

Genetic and tissue level muscle-bone interactions during unloading and reambulation.

Journal of musculoskeletal & neuronal interactions·2016
Same author

Ball flight kinematics, release variability and in-season performance in elite baseball pitching.

Scandinavian journal of medicine & science in sports·2015
Same author

Modulation of bone's sensitivity to low-intensity vibrations by acceleration magnitude, vibration duration, and number of bouts.

Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·2015
Same author

Physical activity engendering loads from diverse directions augments the growing skeleton.

Journal of musculoskeletal & neuronal interactions·2013
Same author

Response of immature bone-ligament junction to a high-fat-sucrose diet.

Clinical biomechanics (Bristol, Avon)·2013

Area of Science:

  • Bone biology
  • Skeletal aging research
  • Comparative pathology

Background:

  • Cortical bone loss is a major factor in age-related skeletal integrity decline.
  • Existing animal models inadequately replicate human age-related cortical bone changes.
  • Understanding these changes is crucial for developing effective interventions.

Purpose of the Study:

  • To investigate if aged rooster cortical bone exhibits phenotypic alterations similar to aged human cortical bone.
  • To evaluate changes in endocortical and periosteal envelopes and cortical porosity in aged roosters.
  • To assess the suitability of roosters as an animal model for age-related bone loss.

Main Methods:

  • Comparative analysis of cortical bone from young adult and aged roosters.

Related Experiment Videos

  • Measurement of endocortical and periosteal envelope expansion.
  • Quantification of cortical porosity and average pore area.

    • Main Results:

    • Aged roosters showed significant endocortical (16%) and periosteal (10%) envelope expansion compared to young roosters.
    • Cortical porosity increased significantly (51%) with a larger average pore area (83%) in aged roosters.
    • These changes led to increased cross-sectional moments of inertia in aged rooster bone.

    Conclusions:

    • Rooster cortical bone displays age-related adaptations at tissue and cellular levels comparable to humans.
    • Roosters represent a potentially useful and cost-effective animal model for studying age-related bone loss mechanisms.
    • Further research using this model can elucidate pathways involved in skeletal aging.