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Autoallergy: a pathogenetic factor in atopic dermatitis?

R Valenta1, S Seiberler, S Natter

  • 1Institute of General and Experimental Pathology, Division of Environmental Dermatology and Allergology GSF/Technical University Munich, Germany.

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|March 17, 2000
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Summary
This summary is machine-generated.

IgE autoantibodies against human proteins may cause severe atopy. These autoallergens can trigger immediate allergic reactions or activate T cells, worsening atopic dermatitis and other chronic allergic conditions.

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Area of Science:

  • Immunology
  • Allergology
  • Dermatology

Background:

  • Immediate-type skin reactions and passive serum transfer in atopy were reported before IgE discovery.
  • Recent findings suggest IgE autoreactivity in severe, chronic atopy.
  • Environmental allergens share structural similarities with human proteins.

Purpose of the Study:

  • To explore the pathogenetic role of IgE autoreactivity in severe and chronic atopy.
  • To investigate the mechanisms underlying IgE autoallergy.

Main Methods:

  • Characterization of autoallergens from human expression cDNA libraries.
  • Production of recombinant autoallergens.
  • Detection of IgE immune complexes in patient sera.

Main Results:

  • Patients with severe atopy have IgE autoantibodies against various human proteins.
  • Autoallergens are primarily intracellular proteins.
  • Some autoallergens are found in IgE immune complexes in sera.

Conclusions:

  • IgE autoallergy may contribute to immediate-type symptoms by cross-linking IgE autoantibodies.
  • IgE-mediated presentation of autoallergens can activate autoreactive T cells, exacerbating allergic tissue reactions.