Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Fetoplacental chromosomal discrepancy.

C Farra1, B Giudicelli, M C Pellissier

  • 1Center for Prenatal Diagnosis, La Timone Hospital, 13385 Marseilles, Cedex 5, France.

Prenatal Diagnosis
|March 17, 2000
PubMed
Summary

Fetoplacental discrepancies in chorionic villus sampling (CVS) can complicate prenatal diagnosis. A positive correlation exists between placental aneuploidy and abnormal fetal development, necessitating further DNA analysis for discrepant karyotype findings.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Salmonella in Malaysia: Outbreaks, contamination sources, serovar distribution and antimicrobial resistance patterns.

Tropical biomedicine·2026
Same author

Children's drinking water sources in the state of Qatar: parental preferences and knowledge of its fluoride content.

European archives of paediatric dentistry : official journal of the European Academy of Paediatric Dentistry·2025
Same author

Detection of Leptospira in environmental samples of wet markets and paddy fields in Penang, Malaysia.

Tropical biomedicine·2025
Same author

The Hall technique: knowledge, practice, and concerns of dentists in primary care settings in the State of Qatar-a questionnaire-based survey.

European archives of paediatric dentistry : official journal of the European Academy of Paediatric Dentistry·2024
Same author

Cost of exome analysis in patients with intellectual disability: a micro-costing study in a French setting.

BMC health services research·2023
Same author

Identification of a novel nonsense variant in <i>FYCO1</i> gene associated with infantile cataract and cortical atrophy.

Ophthalmic genetics·2021

Area of Science:

  • Genetics
  • Prenatal Diagnosis
  • Gynecology

Background:

  • Chorionic villus sampling (CVS) is an alternative to amniocentesis for prenatal genetic diagnosis.
  • Discrepancies between placental and fetal chromosomal constitution (fetoplacental discrepancies) pose diagnostic challenges.
  • Understanding these discrepancies is crucial for accurate prenatal genetic counseling.

Purpose of the Study:

  • To investigate the occurrence and implications of fetoplacental discrepancies identified during prenatal diagnosis.
  • To analyze the correlation between placental chromosomal abnormalities and fetal development.
  • To highlight the importance of further genetic testing when karyotype findings differ between placenta and amniotic fluid.

Main Methods:

  • Retrospective analysis of 26 cases with identified fetoplacental discrepancies.

Related Experiment Videos

  • Cytogenetic analysis of chorionic villi, amniotic fluid, and fetal blood samples.
  • Evaluation of fetal development, including intrauterine growth retardation and uniparental disomy.

    • Main Results:

    • Chromosomal aberrations were confined to the placenta in 21 out of 26 cases.
    • In two cases, abnormalities were found in amniotic fluid and fetal blood but not in chorionic villi.
    • Three cases with confined placental aneuploidy showed intrauterine growth retardation; four of six evaluated cases showed biparental inheritance for uniparental disomy.

    Conclusions:

    • Fetoplacental discrepancies, particularly confined placental aneuploidy, are associated with adverse fetal development.
    • A positive correlation between placental aneuploidy and abnormal fetal development is supported.
    • Further DNA analysis is essential when discrepant karyotype findings arise between placental and amniotic samples.