Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Folate and carcinogenesis: an integrated scheme.

S W Choi1, J B Mason

  • 1Vitamin and Carcinogenesis Program, Jean Mayer U.S. Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, Massachusetts, USA.

The Journal of Nutrition
|March 17, 2000
PubMed
Summary

Folate status significantly impacts cancer risk, particularly in the colorectum. Adequate folate intake may protect against cancer, while deficiency enhances its development through DNA-related mechanisms.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Distinct genetic architecture in the tails of complex traits.

Nature·2026
Same author

Cancer risk in patients with systemic lupus erythematosus: a population-based cohort study in the Republic of Korea 2004-2021.

Scandinavian journal of rheumatology·2025
Same author

Specialist and Patient Perspectives on Strategies to Improve Cardiovascular Disease Prevention Among Persons Living with Psoriatic Disease.

Journal of psoriasis and psoriatic arthritis·2023
Same author

Dynamic Fixation versus Static Screw Fixation for Syndesmosis Injuries in Pronation External Rotation Ankle Fractures: A Retrospective Case Control Study.

Malaysian orthopaedic journal·2023
Same author

Uninsured immigrants in the United States significantly delayed the initiation of prenatal care after the changes to the Public Charge Rule.

Public health·2023
Same author

Augmented Reality From the Benchtop to the Practice of Joint Arthroplasty: Is It Feasible?

The Journal of arthroplasty·2022

Area of Science:

  • Nutritional Biochemistry
  • Cancer Biology
  • Molecular Epidemiology

Background:

  • Folate status is linked to cancer risk, especially colorectal cancer.
  • Folate depletion may promote carcinogenesis, while supplementation appears protective.
  • Mechanisms underlying folate's role in cancer modulation are not fully understood.

Purpose of the Study:

  • To review proposed mechanisms by which folate status influences cancer risk.
  • To integrate current understanding of folate's role in carcinogenesis.
  • To highlight the impact of folate on DNA integrity and methylation.

Main Methods:

  • Review of epidemiological, animal, and human studies.
  • Analysis of mechanistic pathways involving folate metabolism.

Related Experiment Videos

  • Consideration of genetic polymorphisms, such as MTHFR.

    • Main Results:

    • Folate is crucial for S-adenosylmethionine formation (methyl donor) and nucleotide synthesis (DNA/RNA).
    • Folate depletion is associated with DNA hypomethylation, DNA damage, and impaired DNA repair.
    • These DNA alterations can affect tumor suppressor gene and proto-oncogene expression, promoting cancer.

    Conclusions:

    • Folate status plays a significant role in modulating cancer risk, particularly for colorectal cancer.
    • Mechanisms involve folate's impact on DNA methylation, integrity, and repair.
    • Further research into folate metabolism and genetic factors is warranted to elucidate its chemopreventive potential.